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Genome Project - Out of Africa

New research reveals back-to-Africa gene flow from Eurasia to southern African populations


We hear a lot about the ‘Out of Africa’ theory that humans originated in Africa and then migrated to other countries around the world. But a fascinating new study published in the Proceedings of the National Academy of Sciences has revealed a back-to-Africa gene flow in which the genes from west Eurasia spread into southern African populations.

The research team led by Harvard Medical School’s David Reich examined several southern African Khosian populations — broadly defined as indigenous populations that speak non-Bantu languages with click consonants – and compared the DNA to a dataset included 1,040 people from 75 populations worldwide.  They uncovered evidence of two events, one which took place around 3,000 years ago in which there was gene flow from European or Middle Eastern populations to eastern African populations, and the other which traced back to about 1,300 years ago in which gene flow spread from an already mixed east African population to southern Africans.

"The most striking inference from this analysis is the presence of west Eurasian ancestry in southern Africa," said Reich and his colleagues. "Several lines of evidence suggest that the population that brought this ancestry to southern Africa was an already-admixed population from eastern Africa."

Joseph Pickrell, a co-author of the study, said that he and his colleagues had uncovered hints of ancestry from individuals resembling present-day populations in Italy in southern and eastern African populations. This apparent mixing, likely through an intermediate population in eastern African, underscored the effect of uncharacterized back-to-Africa gene flow.

The west Eurasian admixture event with the eastern African populations was the more ancient admixture event.  Still, they added that the ultimate source of this west Eurasian ancestry is an "open question."

While the archaeological record from that timeframe is limited, the researchers said that architecture in Ethiopia from this time period bears a strong resemblance to that of southern Arabia and the timing broadly coincides with the introduction of Ethiosemitic languages to Africa.  Pulling together the genetic, archaeological, and linguistic data, Reich and his colleagues proposed that people from west Eurasia moved into Ethiopia some 3,000 years ago, distributing west Eurasian ancestry throughout the region.

By April Holloway



I was wondering if there is an update for this srticle. Perhaps a new study without software incompatabiltities

I was wondering if there is an update for this srticle. Perhaps a new study without software incompatabiltities

The study was flawed, the researchers admit. Back-into-Africa gene flow was much more restricted than it seemed, due to software incompatibilities

The blog system may not like me giving links, google for "nature" (the highly prestigeous publication) plus "error found in study of first ancient african genome"

you should read :instellar migration and the human experience", it has knowledge in there similar to this that shows we did not come just out of Africa, they traced genetics across the world and has shown multiple results.

Cassi's picture

In addition, I do not mean to deminish the 'value' as not being worthy, only that it is pretty recent for ancient or origin studies :-) But it is of great sideline or confirming value for the aforementioned legend/myth. :-)


aprilholloway's picture


April Holloway is a Co-Owner, Editor and Writer of Ancient Origins. For privacy reasons, she has previously written on Ancient Origins under the pen name April Holloway, but is now choosing to use her real name, Joanna Gillan.

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