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This arc of five hominid skulls has been used for over 100 years to prove that natural selection theory is totally random and accidental, but a new study shows this to be false for a malaria mutation.	Source: Smithsonian

Darwin’s Natural Selection Theory May Not Be True, Gene Study Says

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Researchers from Ghana and the University of Haifa, Israel, have published a breakthrough study that questions randomness in Darwin’s natural selection theory, in the Genome Research journal which may revolutionize human evolutionary history. According to the researchers, mutations have been misattributed to randomness, and this has been the backbone of the theory of evolution, until now. Instead, the researchers have been able to provide evidence of non-random mutations by showing “a long-term direct mutational response to environmental pressure.”

For over 160 years, the scientific community has followed Darwin’s natural selection theory, which basically says nature selects for new mutations in a totally random way. But a new study shows that it may not be randomness at all but environmental pressures that cause mutations. (David Carillet / Adobe Stock)

For over 160 years, the scientific community has followed Darwin’s natural selection theory, which basically says nature selects for new mutations in a totally random way. But a new study shows that it may not be randomness at all but environmental pressures that cause mutations. ( David Carillet / Adobe Stock)

Non-Randomness Versus Accidental Natural Selection Theory

This is in direct contradiction to Darwin’s longstanding theory of natural selection, which argues that all genetic mutations are random and accidental, and attributes beneficial traits being passed on through generations of breeding. For long, this has been a key tenet of neo-Darwinism, but we can now safely postulate that one helpful genetic mutation was not random at all – the human haemoglobin S (Hbs) mutation that protects against malaria.

Lead researcher Professor Adi Livnat, from the University of Haifa, Israel said:

“For over a century, the leading theory of evolution has been based on random mutations. The results show that the HbS mutation is not generated at random but instead originates preferentially in the gene and in the population where it is of adaptive significance. We hypothesize that evolution is influenced by two sources of information: external information that is natural selection, and internal information that is accumulated in the genome through the generations and impacts the origination of mutations.”

Professor Livnat is referring to the unique approach adopted by his team, wherein, the HbS mutation was isolated to distinguish between random mutations, and natural selection. In the mix, non-random mutations were added to detect “de novo” mutations, which literally mean “out of the blue” mutations that are present in an offspring but not inherited from either parent, reported The Daily Mail .

Interestingly, the HbS mutation was found to occur more frequently in populations where malaria is endemic, i.e., Africa, suggesting that certain mutations arise more frequently where they are of adaptive significance. The scientists behind the latest study hypothesize that evolution is influenced both by external information (natural selection), and internal information (generational genetic pools).

For over 160 years, based on Darwin’s natural selection theory, we have been taught that evolution through mutation is random and accidental, but the latest study shows that this isn’t true for malaria. (Exposé GmbH / Adobe Stock)

For over 160 years, based on Darwin’s natural selection theory, we have been taught that evolution through mutation is random and accidental, but the latest study shows that this isn’t true for malaria. ( Exposé GmbH / Adobe Stock)

Lamarckism, Environmental Pressures and De Novo Mutations

This new thinking about natural selection has actually been around for a long time but the recent study proves it for the human hemoglobin malaria mutation.

Many scientists have written that complex and impressive adaptations in the eyes, brain, or hands, cannot be just attributed to randomness. Neither can the entire natural selection process be explained by Lamarckism, which posits that all beneficial adaptations come from direct environmental pressure. When the out-of-the-blue mutation hypothesis is applied to HbS, it is seen to provide protection against malaria for people with one copy, but causes sickle cell anemia in those with two copies, reported Salon.

"This shows empirically for the first time a directional response of mutation to a specific long-term environmental pressure . This sort of result cannot be explained by Neo-Darwinism, which is limited to explaining minor, gross-level effects on average mutation rates, not responses of specific mutations to specific environmental pressures. Therefore, the implications are that here there is an empirical finding that Neo-Darwinism really cannot explain, which challenges the notion of random mutation on a fundamental level,” added Dr Livnat.

Dr Livnat, and his lab manager, Dr Daniel Melamed, applied the de novo emergence of the HbS mutation to its origins, showing that the malaria-protective mutation actually originates de novo more frequently in sub-Saharan Africans , a population subgroup that has been exposed to centuries of malarial selection pressure, compared to that of the Europeans. Clearly, a random mutation would have equally random chances of appearing in both populations, as per Darwinian postulation, but that is not what actually happened.

“Mutations defy traditional thinking. The results suggest that complex information that is accumulated in the genome through the generations impacts mutation, and therefore mutation-specific origination rates can respond in the long-term to specific environmental pressures. Mutations may be generated nonrandomly in evolution after all, but not in the way previously conceived. We must study the internal information and how it affects mutation, as it opens the door to evolution being a far bigger process than previously conceived,” Livnat concluded.

Previous studies using Lamarckism as a theoretical base looked for immediate mutational adaptations to environmental stressors. Other studies, which found Lamarckism too limited in its scope, used only Darwinian natural selection and looked for random internal genetic mutations.

The current study gives scientists motive to reconsider current practices “of measuring mutation rates as averages across a multitude of positions on the genome.” This also opens up the field to study mutations other than HbS to see if the story of human evolution is actually random or smart by design!

Top image: This arc of five hominin skulls has been used for over 100 years to prove that natural selection theory is totally random and accidental, but a new study shows this to be false for a malaria mutation. Source: Smithsonian

By Sahir Pandey

References

JP. 2022. Are genetic mutations random in humans? Israeli study says no . Available at: https://www.jpost.com/science/article-695101

Melamed, D., Nov, Y., et al. 2022. De novo mutation rates at the single-mutation resolution in a human HBB gene-region associated with adaptation and genetic disease. Genome Research. Available at: https://doi:10.1101/gr.276103.12

Morrison, R. 2022. Darwin was wrong! New study suggests for the first time that genetic mutations are NOT always random and may evolve to respond to environmental pressures . Available at: https://www.dailymail.co.uk/sciencetech/article-10465347/New-study-suggests-genetic-mutations-NOT-random.html

Rozsa, M. 2022. Biologists surprised to discover that some "random" mutations may not be so random . Available at: https://www.salon.com/2022/02/05/biologists-surprised-to-discover-that-some-random-mutations-may-not-be-so-random/

Comments

Damn right it’s not true.

riparianfrstlvr's picture

Darwins theory was that, a theory. to me natural selection is either you adapt to, or mutate in or die. desease, starvation, fires, environmental changes of any kind. be they regional, hemispherical, or global, shit happens, and we,  the animals and plants, nature adapts.

riparianfrstlvr

Gary Moran's picture

Too many “isms” for me. I would say that living beings have an innate desire for their species to survive and thrive, so they react to overcome or conquer adverse situations. 

riparianfrstlvr's picture

thank you, i have an effective immune system too. here is my personal science. my PT has 5 relatives that all got 2 and 1 got 3 vaxs. she did not as she has an immune system too. all of them have had covid. 3 days feeling under the weather, my PT lost her sense of smell for 1 day. her bro now since his 2 vaxs, has chronic cardiac arrythmias, tachacardia speeding beating. i may have had covid last summer, but i am not sure. it was so smokey from all of the forest fires. if i did get covid it couldn’t penetrate all of the phlem and ash i was hawking up from all of the forest fires.

riparianfrstlvr

The belief that Darwinism explains evolution is just a relic of the belief of gradualism. The term ‘survival of the fittest’ did not even originate with Darwin – Herbert Spencer introduced the concept. The alternate theory is/was punctuated equilibrium, the idea of Lamarkianism, or catastrophism as applied to other areas of study. Gradualism permeates human psychology due to the human tendency to fear sudden change, and can be observed in every human activity from economic forecasting (forecasts tend to be linear, until they drop off a cliff, thence to be re-forecast linearly) to biology, to the environment, to geological history, to politics. But all these beliefs are just a manifestation of human psychology imposed on the forces of nature. All evidence of history examined objectively reveals a combination of change by increment permeated by infrequent sudden and catastrophic change.

In human and other animal evolution, the internal/external pressure argument could be resolved by recognising that in the male of the species sperm is produced every day and could incorportate response to change in the world whereas female eggs are produced only once in a generation. The male participation represents response to environmental change superimposed on the stability of the female of a species. So, not an either/or but a combination, and the immune system evolves accordingly to challenge new threats, the theory proposed by Lamark. For entirely ‘de novo’ mutations, these are the result of new threats unknown to previous generations but an adapted response to past threats of biologically similar threats/diseases and these adaptations will be passed to succeeding generations, which in turn will be exposed to new threats, ad infinitum.

The current ‘scientific’/political environment proposes that the immune system is no longer relevant and that chemical concoctions are necessary to provide immunity that ‘wanes’, a silly vanity that requires a new ‘vaccine’ for every variant. Shall there be a new ‘vaccine’ for every virus or other threat that comes along? Currently, people are being injected with a vaccine for a virus that disappeared a year ago, thus variants and mutations which anyway are constantly appearing in response to their earlier defeat – by the immune system. Considering that there is an estimate that there are 380 Trillion viruses and 38 Trillion bacteria that most bodies dismiss effectively that hope is ludicrous.

 

 

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