Architectural investigations of the Grand Plaza resulted in the unexpected discovery of a large epidemic cemetery associated with the 1545-1550 cocoliztli epidemic. The cemetery was found to contain numerous mass burials, attesting to the catastrophic nature of the epidemic. An international team, led by researchers from the Max Planck Institute for the Science of Human History (MPI-SHH), Harvard University and the Mexican National Institute of Anthropology and History (INAH), has used ancient DNA and a new data processing program to identify the possible cause of a colonial-era epidemic in Mexico. Many large-scale epidemics spread through the New World during the 16th century but their biological causes are difficult to determine based on symptoms described in contemporaneous historical accounts. In this
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