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Bloodletting was treatment for infection in the past.

In a world with no antibiotics, how did doctors treat infections?

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The development of antibiotics and other antimicrobial therapies is arguably the greatest achievement of modern medicine. However, overuse and misuse of antimicrobial therapy predictably leads to resistance in microorganisms. Alternative therapies have been used to treat infections since antiquity, but none are as reliably safe and effective as  modern antimicrobial therapy . So how were infections treated before antimicrobials were developed in the early 20th century?

Blood, leeches and knives

Bloodletting was used as a medical therapy for over 3,000 years. It originated in Egypt in  1000 B.C.  and was used until the middle of the 20th century.

Medical texts from antiquity all the way up until 1940s recommend bloodletting for a wide variety of conditions, but particularly for infections. As late as 1942, William Osler’s 14th edition of  Principles and Practice of Medicine , historically the preeminent textbook of internal medicine,  included bloodletting as a treatment  for pneumonia.

Bloodletting is based on  an ancient medical theory  that the four bodily fluids, or “humors” (blood, phlegm, black bile and yellow bile), must remain in balance to preserve health. Infections were thought to be caused by an excess of blood, so blood was removed from the afflicted patient. One method was to make an incision in a vein or artery, but it was not the only one. Cupping was another common method, in which heated glass cups were placed on the skin, creating a vacuum, breaking small blood vessels and resulting in large areas of bleeding under the skin. Most infamously, leeches were also used as a variant of bloodletting.

A man sitting in chair, arms outstretched, streams of blood pouring out as a nun places leeches on his body.

A man sitting in chair, arms outstretched, streams of blood pouring out as a nun places leeches on his body. Images from the History of Medicine (NLM)

Interestingly, though bloodletting was recommended by physicians, the practice was actually performed by barbers, or “barber-surgeons.” The red and white striped pole of the barbershop originated as “advertising” their bloodletting services, the red symbolizing blood and the white symbolizing bandages.

There may actually have been some benefit to the practice – at least for certain kinds of bacteria in the early stages of infection. Many bacteria require iron to replicate, and iron is carried on heme, a component of the red blood cell. In theory, fewer red blood cells resulted in less available iron to sustain the bacterial infection.

Some mercury for your syphilis?

Naturally occurring chemical elements and chemical compounds have historically have been used as therapies for a variety of infections, particularly for wound infections and syphilis.

A woodcut from 1689 showing various methods of syphilis treatment including mercury fumigation.

A woodcut from 1689 showing various methods of syphilis treatment including mercury fumigation.  Images from the History of Medicine (NLM)

Topical iodine, bromine and mercury-containing compounds were used to treat infected wounds and gangrene during the American Civil War.  Bromine was used most frequently , but was very painful when applied topically or injected into a wound, and could cause tissue damage itself. These treatments inhibited bacterial cell replication, but they could also harm normal human cells.

Mercury compounds were used to  treat syphilis  from about 1363 to 1910. The compounds could be applied to skin, taken orally or injected. But the side effects could include extensive damage to skin and mucous membranes, kidney and brain damage, and even death. Arsphenamine, an arsenic derivative, was also used in the first half of the 20th century. Though it was effective, side effects included optic neuritis, seizures, fever, kidney injury and rash.

Thankfully, in 1943, penicillin supplanted these treatments and remains the first-line therapy for all stages of syphilis.

Looking in the garden

Over the centuries, a variety of herbal remedies evolved for the treatment of infections, but very few have been evaluated by controlled clinical trials.

One of the more famous herbally derived therapies is quinine, which was used to treat malaria. It was originally isolated from the bark of the cinchona tree, which is native to South America. Today we use a synthetic form of quinine to treat the disease. Before that, cinchona bark was dried, ground into powder, and mixed with water for people to drink. The use of cinchona bark to treat fevers was described by Jesuit missionaries in the 1600s, though it was likely used in native populations much earlier.

An engraving of a Quinine plant, 1880.

An engraving of a Quinine plant, 1880. Wellcome Library, London,  CC BY

Artemisinin, which was synthesized from the  Artemisia annua  (sweet wormwood) plant is another effective malaria treatment. A Chinese scientist,  Dr. Tu Youyou , and her team analyzed ancient Chinese medical texts and folk remedies, identifying extracts from  Artemisia annua  as effectively inhibiting the replication of the malaria parasite in animals. Tu Youyou was coawarded the 2015 Nobel Prize in Physiology or Medicine for the discovery of artemisinin.

You probably have botantically derived therapy against wound infection in your kitchen cupboard. The use of honey in wound healing dates back to the  Sumerians in 2000 B.C. . The high sugar content can dehydrate bacterial cells, while acidity can inhibit growth and division of many bacteria. Honey also has an enzyme, glucose oxidase, that reduces oxygen to hydrogen peroxide, which kills bacteria.

The most potent naturally occurring honey is thought to be  Manuka honey . It is derived from the flower of the tea tree bush, which has additional antibacterial properties.

Like other botanically derived therapies, honey has inspired the creation of pharmaceuticals. MEDIHONEY®, a  medical grade product  developed by Derma Sciences, is used to promote healing in burns as well as other types of wounds.

Combating antimicrobial resistance

While some of these ancient therapies proved effective enough that they are still used in some form today, on the whole they just aren’t as good modern antimicrobials at treating infections. Sadly, thanks to overuse and misuse, antibiotics are becoming less effective.

Each year in the United States, at least  two million people  become infected with bacteria that are resistant to antibiotics, and at least 23,000 people die each year as a direct result of these infections.

While resistant bacteria are most commonly reported, resistance also can arise in other microorganisms, including fungi, viruses and parasites. Increasing resistance has raised the possibility that certain infections may eventually be untreatable with the antimicrobials we currently have.

The race is on to find new treatments for these infections, and researchers are exploring new therapies and new sources for antibiotics.

Featured image: Bloodletting was treatment for infection in the past. Wellcome Library, London, CC.

The article ‘ In a world with no antibiotics, how did doctors treat infections? ’ by Cristie Columbus was originally published on The Conversation and has been republished under a Creative Commons license.

Comments

This was written by those with a vested interest in keeping humanity dumbed down.
Cristie Columbus, Vice Dean, Texas A&M College of Medicine, Texas A&M University
The Farm, supplying the Pharmacy had all kinds of herbs like Comfrey for the treatment of bacterial infections.
The author actually makes it look like "doctors" of olde (read 'healers', practitioners of the wise craft and medicine (wo)men) were barbaric in their traditional methods which fails to examine the effectiveness of any traditional healing modality.
One would have expected more research from a woman in such a place of high esteem.
But thats the future of medicine where 'doctors' are paid drug pushers for the Pharmageddics industry.

In a 17th century medical book I read a physician thought he saw better results using bark from the tulip poplar to treat malaria.

yes, of course! It is very exciting to see how a lousy article which gives history a short shift can bring out the best in astute readers---how did we ever as humans not only exist but thrive prior to antibiotics one must wonder...most folks had herbal gardens as part of their vegetable gardens..I was quite astounded this past winter when struck with a respiratory infection how quickly it was extinguished by the mundane garden sage leaves I had hastily dried for culinary use came to the rescue, steeped in hot water and tempered with honey....locally grown herbs unprocessed seem to pack a more potent punch than store bought ones (whose age is uncertain) A very materialistic medical establishment is forcing many to become their own doctors as costs and indifference turn more and more patients to seek alternatives...

Don't forget the fantastic healing from oil of oregano.

Silver has a long tradition in the households of the elite to ward against bacteria and infection, hence the usage of silverware---especially cups for drinking--babies were fed with silver spoons and given silver spoons to suck on much like a pacifier. Copper is also a potent anti-germinal with a long history in medicine. These ancient practices are not merely forgotten--they are banned by a pharmaceutical industry which would rather use toxic drugs that have an enormous profit and a huge plethora of side effects. Since these practices are not being taught and banished from history it is up to adventurous healers and alternative practitioners to rediscover them and utilize them. Iodine has a very well documented history of curing many many diseases as well as turpentine, castor oil and many potent herbs like thyme, sage and rosemary. Antibiotics are becoming almost useless so these old timey methods may reappear sooner than later --and people who practice alternative medicine have been using them successfully for decades. Mercury is certainly not something worth re-examining, of course.

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